Implications for Interleukin-33 in solid organ transplantation

Article ID	Journal	Published Year	Pages	File Type
5897361	Cytokine	2013	12 Pages	PDF

Abstract

âº IL-33 is expressed in the epithelium and vasculature of transplanted solid organs. âº Distinct domains allow IL-33 to act as a cytokine and a regulatory nuclear factor. âº IL-33 is a pleiotropic cytokine that promotes Type-1, -2 and regulatory responses. âº Data support a protective role for IL-33 following heart transplantation. âº IL-33 may contribute to poor lung or intestine transplant outcomes.

Keywords

LTX BAL TLR IL-1RA NLS ST2 IL-1RAcP IVIg ILC2 DSA Treg ITx DC-SIGN Chronic Allograft Vasculopathy MDSC HTH TNF IL1RL1 IL-1R accessory protein CAV HEV APC CBM TCr FOXP3 i.p.HTx I/R sST2 Rheumatoid arthritis IL-1 receptor antagonist donor specific antibodies ischemia/reperfusion immunoglobulin interferon IFN interleukin Interleukin-33 Intravenous immunoglobulin TIR Toll-like receptor forkhead box P3 intraperitoneal Immunosuppression Regulatory T cell Dendritic cells Myeloid-derived suppressor cells Helper T cell antigen presenting cell nuclear localization signal IRAK tumor necrosis factor bronchoalveolar lavage soluble ST2 type 2 innate lymphoid cell Alarmin helix-turn-helix high endothelial venules Transplantation Intestinal transplantation Lung transplantation Heart transplantation murine IL-1 receptor-associated kinase T cell receptor