| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5897621 | Cytokine | 2013 | 7 Pages |
Abstract
⺠Serotonin and IL-10 are involved in intestinal homeostasis and pathophysiology. ⺠Serotonin transporter regulation by IL-10 was studied in Caco-2 cells. ⺠IL-10 at a low concentration inhibited SERT activity. ⺠IL-10 at a high concentration increased SERT activity and membrane expression. ⺠IL-10 modulates SERT and serotonin availability depending on intestinal conditions.
Keywords
PI3KIL10RAIL-10RIL10RBPDTCIL-10NF-κB5-HTIBDIBS5-hydroxytryptamine, serotoninp38 MAPKInterleukin-10inflammatory bowel diseasesGastrointestinalIntestineSERTserotonin transporterCaco-2 cellsirritable bowel syndromesulfasalazinenuclear factor-κBphosphatidylinositol 3 kinasep38 mitogen activated protein kinasepyrrolidinedithiocarbamateinterleukin-10 receptor
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Authors
Eva Latorre, Carmen Mendoza, Nyurky Matheus, Marta Castro, Laura Grasa, José E. Mesonero, Ana I. Alcalde,