Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5897944 | Cytokine | 2012 | 7 Pages |
Abstract
⺠TNF activates lymphotoxin-beta transcription. ⺠NF-κB and Ets cis-acting transcriptional elements mediate TNF activation. ⺠NF-κB p50 and p65 bind lymphotoxin-beta promoter sequences. ⺠Ets1 binds the promoter in vivo. ⺠Ets1 overexpression transactivates the lymphotoxin-beta gene.
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Authors
Lily S. Subrata, Dominic C. Voon, George C.T. Yeoh, Daniela Ulgiati, Elizabeth A. Quail, Lawrence J. Abraham,