| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5897953 | Cytokine | 2012 | 12 Pages |
Abstract
⺠Sildenafil effects on cerebellum were studied in a multiple sclerosis mice model. ⺠CPZ increased GFAP and Iba-1 expression, and sildenafil inhibited this effect. ⺠Sildenafil had an anti-inflammatory effect, decreasing cytokines/COX-2 levels. ⺠Sildenafil inhibited CPZ-induced demyelination in the cerebellum. ⺠The data suggest a beneficial effect of PDE5 inhibition in CNS injury.
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Authors
Ana Karolina de Santana Nunes, Catarina Rapôso, Rayana Leal de Almeida Luna, Maria Alice da Cruz-Höfling, Christina Alves Peixoto,