| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898005 | Cytokine | 2012 | 7 Pages |
Abstract
⺠The complete or partial IFNAR sequences of the two woodchuck species were obtained. ⺠RNA interference was performed to verify the biological functions of the IFNAR. ⺠IFNAR expression was significantly up-regulated by stimulation with IFN in vitro. ⺠IFNAR expression in liver of chronically WHV-infected woodchuck was down-regulated. ⺠This work provides a basis for studying type I IFN system in the woodchuck model.
Keywords
HMGB1High-mobility group protein B1pWHIL15complete coding sequenceWHVISGPBMCHCCIFNARinterferonIFNInterleukin 15peripheral blood mononuclear cellsHBVHepatitis C virusHCVWoodchuckhepatitis B virusWoodchuck hepatitis virusSingle-nucleotide polymorphismSNPIFN-stimulated genesCdSHepatocellular carcinomatype I interferon receptor
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Authors
Hebin Fan, Zhenni Zhu, Yang Wang, Xiaoyong Zhang, Yinping Lu, Yuanqing Tao, Wei Fan, Zhongdong Wang, Hu Wang, Micheal Roggendorf, Mengji Lu, Baoju Wang, Dongliang Yang,