| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898017 | Cytokine | 2012 | 7 Pages |
Abstract
⺠Hypoxia activates monocytic THP-1 cells to express Wnt5a. ⺠Wnt5a rapidly induces CXC chemokines and pro-inflammatory cytokines in THP-1 cells. ⺠Wnt5a activates THP-1 cells via β-catenin-independent Wnt signaling. ⺠Wnt5a activates NF-κB and JNK in THP-1 cells. ⺠Wnt5a-induced NF-κB activation is JNK-dependent.
Keywords
PCPWNT5AIKKNF-κBXIAPPKCHAECsMnSODFHCIkB kinaseFBSJnkLPSc-Jun N-terminus kinaseMAPKMKKUltravioletinterferonIFNRelAfetal bovine serumhuman aortic endothelial cellsnuclear factor kappa BPlanar Cell PolaritylipopolysaccharideMacrophagemanganese-superoxide dismutaseX-linked inhibitor of apoptosisProtein kinase Cmitogen-activated protein kinase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Jungtae Kim, Wookyoung Chang, Yusun Jung, Kyuyoung Song, Inchul Lee,