| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898043 | Cytokine | 2012 | 9 Pages |
Abstract
⺠We find that IL-6 secreted by OVCA cells promotes malignant behavior of these cells. ⺠IL-6 promotes OVCA cell proliferation by altering cell cycle distribution. ⺠IL-6 stimulates cell proliferation via activation of Raf/MEK/ERK and PI3K/Akt. ⺠IL-6-enhanced cell invasive correlates with increased MMP-9 but not MMP-2 activity. ⺠Regulation of IL-6 may be a promising strategy for controlling OVCA progression.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Yue Wang, Lingzhi Li, Xiaoqin Guo, Xin Jin, Weijia Sun, Xiaolei Zhang, Rui Cheng Xu,