| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898045 | Cytokine | 2012 | 7 Pages |
Abstract
⺠The tryptophan-degrading enzyme, IDO was investigated following T. gondii infection. ⺠Depleted tryptophan in the lung was occurred in wild-type, but not in IDO KO mice. ⺠The inhibition of increased IDO activity attenuates T. gondii replication. ⺠The inhibition of increased IDO activity reduced the inflamed damage in the lung. ⺠Kynurenine pathway may play a key role following T. gondii infection.
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Authors
Yuki Murakami, Masato Hoshi, Akira Hara, Masao Takemura, Yuko Arioka, Yasuko Yamamoto, Hidetoshi Matsunami, Tadao Funato, Mitsuru Seishima, Kuniaki Saito,