| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898104 | Cytokine | 2012 | 8 Pages |
Abstract
⺠IL-3 in combination with TNF induces exuberant amounts of eosinophil MMP-9. ⺠The synergistic effect of IL-3/TNF is due to MMP-9 synthesis by eosinophils. ⺠Enhanced mRNA stabilization is associated with the synergistic induction of MMP-9. ⺠MMP-9 synthesis requires the interaction of multiple signaling pathways. ⺠Targeting IL-3/TNF may impede MMP-9-mediated tissue injury/remodeling.
Keywords
ECMIL-5GUSIL-3ERKMMP-9qPCRβCTNFMMPNF-κBSDS–PAGEsodium dodecyl sulfate–polyacrylamide gel electrophoresistumor necrosis factor alphamRNA stabilityquantitative real time PCRnuclear factor kappa BExtracellular matrixmatrix metalloproteinaseMEKUTR یا untranslated regions untranslated regionmapAntibodymitogen-activated protein kinaseExtracellular signal-regulated protein kinasemitogen-activated protein kinase kinaseMAP kinaseGlucuronidase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Elizabeth A.B. Kelly, Lin Ying Liu, Stephane Esnault, Beatriz Helena Quinchia Johnson, Nizar N. Jarjour,