| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898114 | Cytokine | 2012 | 8 Pages |
Abstract
⺠Bone marrow stromal cells and osteoblasts demonstrate reduced IL-6 expression in response to chemotherapy exposure. ⺠Melphalan more dramatically induces IL-6 reduction than a variety of other agents evaluated. ⺠IL-6 remains effectively reduced by melphalan even in the setting of myeloma and osteoblast or stromal cell co-culture. ⺠Previously characterized IL-6 polymorphisms do not correlate with stromal cell response to chemotherapy.
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Authors
Stephanie L. Rellick, Debbie Piktel, Cheryl Walton, Brett Hall, William Petros, James E. Fortney, Marieta Gencheva, Jim Denvir, Gerald Hobbs, Michael Craig, Laura F. Gibson,