Article ID Journal Published Year Pages File Type
5898174 Cytokine 2011 8 Pages PDF
Abstract
► Rh-EPO induced up-regulation of phosphorylated JAK2 and STAT3 following TBI. ► Rh-EPO enhanced Bcl-2 and Bcl-xl expression and increased cortical cell survival. ► AG490 attenuated rhEPO-induced activation of JAK2/STAT3 after TBI. ► AG490 inhibited Bcl-2 and Bcl-xl expression and exaggerated cortical cell apoptosis.
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Preview
The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats
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