| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898214 | Cytokine | 2011 | 5 Pages |
Abstract
⺠The cytokine lymphotoxin-α (LTα) is a promising anticancer agent. ⺠PEGylation is the approach to enhance the therapeutic potential of protein. ⺠Here, we created a lysine-deficient mutant LTα (LT-K0) by phage display. ⺠N-terminus-specific PEGylation of LT-K0 had higher bioactivity than PEGylated LTα. ⺠These results suggest that PEGylated LT-K0 may be useful in cancer therapy.
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Authors
Shogo Narimatsu, Yasuo Yoshioka, Hikaru Watanabe, Takashi Masano, Tomohiro Morishige, Xinglei Yao, Aya Tanabe, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa,