| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898267 | Cytokine | 2012 | 11 Pages |
Abstract
⺠IFNγ down regulates phagocytosis by FcγR without modifying early signaling events. ⺠IFNγ induces higher basal F-actin levels by a mechanism that involves PI3K. ⺠IFNγ activates Rac1 but not Cdc42. ⺠After IFNγ treatment, F-actin levels are not modified by FcγR or CCL5 stimulation. ⺠Higher basal F-actin levels compromises cell responses to additional stimulation.
Keywords
PFAreceptor for the Fc portion of IgGmonocyte derived macrophagesGMFITAMTNBSgeometric mean of fluorescence intensityFcγRMDMSRBCDBAF-actinHRPPI3KmAbFBSMFI2,4,6-Trinitrobenzene sulfonic acid3,3′-diaminobenzidineMonoclonal antibodyfetal bovine serumPhagocytosisMacrophagesimmunoreceptor tyrosine-based activation motifmean fluorescence intensityparaformaldehydeHorseradish peroxidaseCytoskeletonsheep red blood cells
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Authors
Dulce Frausto-Del-RÃo, Isabel Soto-Cruz, Claudia Garay-Canales, Xochitl Ambriz, Gloria Soldevila, Jorge Carretero-Ortega, José Vázquez-Prado, Enrique Ortega,