| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898287 | Cytokine | 2011 | 9 Pages |
Abstract
⺠Interferon regulatory factor-4 binds to an NF-kappaB family member, c-Rel, in T-cells. ⺠The N-terminal half of c-Rel bound to the C-terminal IRF association domain of IRF-4. ⺠IRF-4 and c-Rel bound to the interleukin-4 (IL-4) promoter region. ⺠Exogenously-expressed IRF-4 and c-Rel enhanced the IL-2 production in T-cells. ⺠IRF-4 was indispensable for the optimal IL-2 and IL-4 productions in vivo.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Hisakazu Shindo, Kiyoshi Yasui, Kazuo Yamamoto, Kiri Honma, Katsuyuki Yui, Tomoko Kohno, Yuhua Ma, Koon Jiew Chua, Yoshinao Kubo, Hitoshi Aihara, Takashi Ito, Takeshi Nagayasu, Toshifumi Matsuyama, Hideki Hayashi,