| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898372 | Cytokine | 2011 | 7 Pages |
Abstract
⺠Calcitriol stimulated PRL in resting lymphocytes by a VDR-mediated mechanism. ⺠CYP24A1 induction by calcitriol is stronger in resting vs. activated lymphocytes. ⺠Factors restraining VDR-transcriptional process are induced upon activation. ⺠Lymphocyte activation reduced CYP24A1 while induced CYP27B1 and VDR gene expression. ⺠Calcitriol actions in resting lymphocytes are probably mediated by a VDR variant.
Keywords
PRLPBMNCT helperPXRRXRVDRCYP24A1Retinoid X receptorqPCRPhytohemagglutininEC50PHA1,25-dihydroxyvitamin D3reverse transcriptionperipheral blood mononuclear cellsMononuclear cellshalf maximal effective concentrationReal time polymerase chain reactionVitamin DProlactinCalcitriolvitamin D3 receptorPregnane X receptor
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Authors
Lorenza DÃaz, Isela MartÃnez-Reza, RocÃo GarcÃa-Becerra, Leticia González, Fernando Larrea, Isabel Méndez,