Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

Article ID	Journal	Published Year	Pages	File Type
5898384	Cytokine	2011	9 Pages	PDF

Abstract

âº In sepsis, the vessel-protective Tie2 ligand Angiopoietin-1 is suppressed. âº Administration of Angiopoietin-1 protects against sepsis-associated organ dysfunction. âº Administration of Angiopoietin-1 improves survival time in experimental sepsis. âº Ang-1/Tie2 is a promising target to improve endothelium barrier in sepsis.

Keywords

MCP-1 ARDS VCAM-1 angiopoietin-2 MODS PFA BAL CLP angiopoietin-1 ICAM-1 Macrophage chemoattractant protein-1 AKI IL-6 PBS Ang-1 Ang-2 acute kidney injury Acute lung injury angiopoietin Ali Cecal ligation and puncture interleukin-6 Survival Tie-2 Multiple-organ dysfunction syndrome Acute respiratory distress syndrome Sepsis broncho-alveolar lavage Phosphate-buffered saline vascular cell adhesion molecule-1 paraformaldehyde

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Acute administration of recombinant Angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis

Authors

Sascha David, Joon-Keun Park, Matijs van Meurs, Jan G. Zijlstra, Christian Koenecke, Claudia Schrimpf, Nelli Shushakova, Faikah Gueler, Hermann Haller, Philipp Kümpers,