Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5898401 | Cytokine | 2011 | 14 Pages |
Abstract
The C/EBP family of proteins represents an important group of bZIP transcription factors that are key to the regulation of essential functions such as cell cycle, hematopoiesis, skeletal development, and host immune responses. They are also intimately associated with tumorigenesis and viral disease. These proteins are regulated at multiple levels, including gene induction, alternative translational initiation, post-translational modification, and protein-protein interaction. This review attempts to integrate recent reports with more than 20 years of previous effort focused on this fascinating collection of regulators.
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Authors
Junichi Tsukada, Yasuhiro Yoshida, Yoshihiko Kominato, Philip E. Auron,