Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes - A longitudinal study in the Vara-Skövde Cohort

•Endothelin-1 may predict impaired glucose tolerance and type 2 diabetes in women.•Endothelin-1 and impaired glucose metabolism (IGM) was not associated in men.•Endothelin-1 exhibits apparent sex differences as a predictor of IGM.

We addressed whether endothelin-1, a marker of endothelial dysfunction, predicts impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in a population study in south-western Sweden. Follow-up after 9.7 years showed an association between circulating endothelin-1 levels at baseline and development of IGT/T2DM in women but not in men.