National trends in incidence and outcomes in lower extremity amputations in people with and without diabetes in Spain, 2001-2012

•For T1DM incidence of minor LEA decreased by 9.84% per year from 2001 to 2008.•For T2DM incidence of minor LEA procedures increased by 1.89% per year from 2001 to 2012.•For T1DM, major LEA incidence decreased by 10.51% per year from 2001 to 2012.•For T2DM, major LEA incidence increased by 4.29% per year from 2001 to 2004, and then decreased by 1.85% per year through 2012.•IHM was associated with higher age in all groups and with being female in T2DM.

AimsTo describe trends in the incidence and outcomes of lower-extremity amputations (LEAs) in patients with T1DM and T2DM in Spain, 2001-2012.MethodsWe used national hospital discharge data. Incidence of discharges attributed to LEA procedures were calculated stratified by diabetes status and type of LEA. Joinpoint log-linear regression for incidence trends and logistic regression for factors associated with in-hospital mortality were used.ResultsFrom 2001 to 2012, 73,302 minor LEAs and 64,710 major LEAs were performed. We found that incidence of minor LEA procedures in T1DM patients decreased by 9.84% per year from 2001 to 2008 and then remained stable through 2012. In T2DM patients, LEA increased by 1.89% per year over the entire study period. Among patients with T1DM, major LEA incidence rate decreased by 10.5% from 2001 to 2012. In patients with T2DM, it increased by 4.29% from 2001 to 2004, and then decreased by 1.85% through 2012. In-hospital mortality after major or minor LEAs was associated with older age in all groups and with being female in T2DM and in people without diabetes.ConclusionsOur national data show a decrease in the incidence of minor LEAs in patients with diabetes and in major LEAS in patients with T1DM over the period of study. In patients with T2DM, we found a decrease between 2004 and 2012. An additional improvement in preventive care, such as the introduction of diabetes foot units in hospitals, is necessary.