| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5899309 | Diabetes Research and Clinical Practice | 2015 | 4 Pages |
Abstract
â¢We conducted a study of Japanese type 2 diabetes patients taking sitagliptin.â¢We found a slight elevation of Cr in the subjects treated with sitagliptin.â¢The new finding is a correlation between elevation of Cr and reduction of HbA1c.â¢Cr elevation is associated with activation of incretin, with up-regulation of GLP-1.
We found a slight elevation of serum creatinine in the subjects treated with sitagliptin for 2 years and a correlation between creatinine elevation and HbA1c reduction. These results suggest that creatinine elevation is associated with activation of incretin, most possibly with up-regulation of diuretic activity of GLP-1.
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Authors
Hajime Maeda, Akira Kubota, Akira Kanamori, Yasushi Tanaka, Yasuo Terauchi, Ikuro Matsuba, The Study Group of the Diabetes Committee, Kanagawa Physicians Association The Study Group of the Diabetes Committee, Kanagawa Physicians Association,