Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5899820 | Diabetes Research and Clinical Practice | 2014 | 11 Pages |
Abstract
Sitagliptin attenuated MCD diet-induced hepatic steatosis, inflammation, and fibrosis in mice through amelioration of mechanisms responsible for the development of NASH, including CD36 expression, NF-κB activation, ER stress, CYP2E1 expression, and lipid peroxidation. Treatment with sitagliptin may represent an effective approach for the prevention and treatment of NASH.
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Authors
Yun-A. Jung, Yeon-Kyung Choi, Gwon-Soo Jung, Hye-Young Seo, Hye-Soon Kim, Byoung Kuk Jang, Jung-Guk Kim, In-Kyu Lee, Mi-Kyung Kim, Keun-Gyu Park,