| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5900681 | Frontiers in Neuroendocrinology | 2011 | 10 Pages |
Abstract
⺠Spinobulbar muscular atrophy (SBMA) is caused by CAG expansion in androgen receptor. ⺠SBMA is triggered by the binding of mutant androgen receptor to testosterone. ⺠Protein context/structure dictates disease features. ⺠Alteration of the native function of the disease protein is critical for pathogenesis. ⺠Towards development of therapy for SBMA.
Keywords
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Authors
Sara Parodi, Maria Pennuto,