| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5900700 | Frontiers in Neuroendocrinology | 2011 | 17 Pages |
Abstract
⺠Estradiol pretreatment attenuates ischemia-induced death of hippocampal neurons. ⺠Estradiol given immediately after ischemia is highly neuroprotective. ⺠Estradiol treatment improves cognitive outcomes after global ischemia. ⺠Estrogens retain their neuroprotective efficacy in hormone-withdrawn older females. ⺠The transcription factor CREB may be a downstream mediator of estradiol protection.
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Authors
Anne M. Etgen, Teresa Jover-Mengual, R. Suzanne Zukin,