| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5900709 | Frontiers in Neuroendocrinology | 2012 | 18 Pages |
Abstract
⺠Activation of the CRH neuron by stress results in CRH release coupled to transient induction of transcription. ⺠All signaling pathways activated by stress in the CRH neuron phosphorylate CREB but only cyclic AMP induces CRH transcription. ⺠Phosphorylation of CREB and its binding to the CRH promoter CRE is not sufficient for initiation of CRH transcription. ⺠CRH transcription requires cyclic AMP-dependent activation and nuclear translocation of the CREB co-activator, TORC. ⺠Glucocorticoid feedback and intraneuronal autoregulatory mechanisms limit the duration of CRH transcriptional responses.
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Authors
Greti Aguilera, Ying Liu,