Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function

Article ID	Journal	Published Year	Pages	File Type
5900900	General and Comparative Endocrinology	2015	35 Pages	PDF

Abstract

Signaling cascades control numerous aspects of sperm physiology, ranging from creation to fertilization. Novel aspects of several kinases and their influence on sperm development will be discussed in the first section and cover proliferation, chromatin remodeling and morphology. In the second section, protein kinases (A, B and C) that affect sperm function and their regulation by second messengers, cyclic-AMP and phosphoinositides, as well as steroids will be featured. Key areas of integration will be presented on the topics of sperm motility, capacitation, acrosome reaction and fertilization.

Keywords

Epac NOS PTP pKa CaMK IP3 CFTR cdk5 PLC MARCKS GSK3 PKC PYK2 MRP4 AMPK PDGF CK2 PDK1 CaMKK Jnk1 ARF6 ODF nek2 ZIP kinase RSK2 ADP ribosylation factor 6 myristoylated alanine-rich C-kinase substrate ANR PI3K CREB DHT PLD IGF FAK EGFR AMP-activated protein kinase c-Jun N-terminal kinase cAMP ERK/MAPK iGFR inositol 1,4,5-trisphosphate MAPK kinase PI(3,4,5)P3 ROS Ribosomal s6 kinase cyclic adenosine 3′,5′-monophosphate adenylyl cyclase Akt Steroids spermatozoa γ-aminobutyric acid Syk proline-rich tyrosine kinase 2 Dihydrotestosterone cystic fibrosis transmembrane conductance regulator Star cyclin-dependent kinase 5 spleen tyrosine kinase platelet-derived growth factor Insulin-like growth factor phosphatase and tensin homologue deleted on chromosome 10 phosphatidylinositol-3,4,5-trisphosphate phosphatidylinositol 4,5-bisphosphate Phosphoinositide Protein tyrosine phosphorylation phospholipase C Phospholipase D phosphoinositide-3 kinase Outer dense fibers MEK Nitric oxide nitric oxide synthase phosphoinositide-dependent kinase 1 Exchange protein directly activated by cAMP Steroidogenic acute regulatory protein protein kinase A protein kinase B Protein kinase C Progesterone second messenger Pten casein kinase II CREm Kinase focal adhesion kinase GABA glycogen synthase kinase-3 Reactive oxygen species IGF-1 receptor Androgen Receptor Estrogen receptor Epidermal growth factor receptor