Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5901054 | General and Comparative Endocrinology | 2014 | 12 Pages |
Abstract
As we approach the end of two decades of leptin research, the comparative biology of leptin is just beginning. We now have several leptin orthologs described from nearly every major clade among vertebrates, and are moving beyond gene descriptions to functional studies. Even at this early stage, it is clear that non-mammals display clear functional similarities and differences with their better-studied mammalian counterparts. This review assesses what we know about leptin function in mammals and non-mammals, and gives examples of how these data can inform leptin biology in humans.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Richard L. Londraville, Yazmin Macotela, Robert J. Duff, Marietta R. Easterling, Qin Liu, Erica J. Crespi,