An efficient one-pot three-component synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives using starch solution as catalyst

Tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives were synthesized via a one-pot three-component condensation of aromatic aldehydes with malononitrile and dimedone or 4-hydroxycoumarin in excellent yields in the presence of starch solution as a highly efficient homogenous catalyst. The use of a nontoxic and biodegradable catalyst, simple work-up procedure, and short reaction time are advantages of this method.

Graphical AbstractTetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives were synthesized via one-pot three-component condensation of aromatic aldehydes with malononitrile and dimedone or 4-hydroxycoumarin in excellent yields in the presence starch solution as a highly efficient homogenous catalyst. The use of a nontoxic and biodegradable catalyst, simple work-up procedure, and short reaction time are advantages of this method.Figure optionsDownload full-size imageDownload as PowerPoint slide