Article ID Journal Published Year Pages File Type
5901668 General and Comparative Endocrinology 2011 7 Pages PDF
Abstract
► This study was conducted to understand pregnenolone formation in the newt brain. ► P450 side-chain cleavage enzyme (P450scc) catalyzes pregnenolone formation. ► We first demonstrated that the newt brain produces pregnenolone from cholesterol. ► Subsequently, cDNA encoding P450scc was isolated from the newt. ► Finally, the site of P450scc mRNA expression was localized in the newt brain.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
Preview
Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster
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