Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5901668 | General and Comparative Endocrinology | 2011 | 7 Pages |
Abstract
⺠This study was conducted to understand pregnenolone formation in the newt brain. ⺠P450 side-chain cleavage enzyme (P450scc) catalyzes pregnenolone formation. ⺠We first demonstrated that the newt brain produces pregnenolone from cholesterol. ⺠Subsequently, cDNA encoding P450scc was isolated from the newt. ⺠Finally, the site of P450scc mRNA expression was localized in the newt brain.
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Authors
Minoru Takase, Shogo Haraguchi, Itaru Hasunuma, Sakae Kikuyama, Kazuyoshi Tsutsui,