Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5902038 | Journal of Diabetes and its Complications | 2016 | 7 Pages |
Abstract
Patients with macro (n = 78) or non-persistent microalbuminuria (n = 81) at baseline were excluded. Odds ratios for endpoints in relation to high versus low (defined using a median split) biomarker levels are found in Fig. 1. Our study demonstrates that high levels of AGE-LDL as well as of IgG antibodies (but not IgM antibodies) reacting with MDA-LDL lysine epitopes in circulating IC predict the development of macroalbuminuria in patients with type 2 diabetes. These data support the pathogenic role of modified LDL IgG antibodies but not the protective role of modified LDL IgM antibodies.
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Authors
Maria F. Lopes-Virella, Kelly J. Hunt, Nathaniel L. Baker, Gabriel Virella, VADT Group of Investigators VADT Group of Investigators,