Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5902275 | Journal of Diabetes and its Complications | 2015 | 34 Pages |
Abstract
All together, the results suggested that gHSA-enhanced ROS production in endothelium is mediated by: 1) NF-κB activation and subsequence up-regulation of NADPH oxidase, 2) eNOS uncoupling. AP-1, although is not directly affected by gHSA, is another target for regulating NADPH oxidase and eNOS expression in endothelial cells.
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Authors
Bruno K. Rodiño-Janeiro, Beatriz Paradela-Dobarro, Sergio Raposeiras-RoubÃn, Mercedes González-Peteiro, José R. González-Juanatey, Ezequiel Álvarez,