| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5902741 | Journal of Diabetes and its Complications | 2013 | 7 Pages |
Abstract
The apoptosis of the retinal cells was confined to the GCL, in which CGRP was normally located. A significant increase in the apoptosis ratio (PÂ <Â 0.05) was observed in the STZ treated animals and high glucose incubated retina, with reductions of CGRP. The pre-treatment with capsaicin effectively up-regulated CGRP and its encoding mRNA and attenuated the cell apoptosis and caspase-3 activity in the retina. The increases of the cell apoptosis in the retina may be related to the down-regulation of endogenous CGRP in diabetes. Capsaicin may attenuate the apoptosis of the retina cells at early times of diabetes, via up-regulation of CGRP.
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Authors
Ji-Hong Yang, Zheng Guo, Ting Zhang, Xian Xian Meng, Tao Sun, Juan Wu,