Intracellular leptin signaling following effective weight loss

Article ID	Journal	Published Year	Pages	File Type
5903047	Metabolism	2015	21 Pages	PDF

Abstract

A 10%-15% weight loss decreases baseline STAT3 phosphorylation ex vivo, but does not alter the effect of increasing doses of leptin on the incremental intracellular phosphorylation of STAT3, ERK, Akt and AMPK. Supraphysiologic leptin doses (75Â ng/ml) result in higher protein phosphorylation compared to either physiologic doses or no treatment, before and after weight loss.

Keywords

STAT3 MNT VLDL-C BIA LEPR PBMCs HDL-C LDL-C HOMA-IR ALT ERK AMPK IGF AST alanine transaminase STAT Akt bioelectrical impedance analysis aspartate transaminase peripheral blood mononuclear cells body mass index BMI Insulin-like growth factor Leptin leptin signaling high-density lipoprotein cholesterol Signal transducer and activator of transcription Obesity protein kinase B Weight loss Low-density lipoprotein cholesterol Very low-density lipoprotein cholesterol extracellular-signal-regulated kinase Leptin receptor