Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903061 | Metabolism | 2016 | 52 Pages |
Abstract
These findings suggest that atorvastatin exerts favorable influence on progression of IR and pancreatic inflammation and fibrosis via pleiotropic effect such as anti-oxidative property.
Keywords
α-SMAPSCsOtsuka Long–Evans Tokushima FattyOLETFT2DMHMG-CoA8-OHdGHOMA-IRFFA4-HNETGF-β13-hydroxy-3-methylglutaryl-coenzyme A4-hydroxy-2-nonenal8-hydroxy-2'-deoxyguanosineAUCMPOH&EivGTTT-choAtorvastatinintravenous glucose tolerance testhomeostasis model assessment of insulin resistanceFree fatty acidsα-smooth muscle actinTransforming growth factor-β1triglyceridetumor necrosis factor-αType 2 diabetes mellitusLETOSODPancreatic Stellate CellsSuperoxide dismutaseTNF-αpancreatic fibrosisInsulin resistancearea under curveOLETF ratmyeloperoxidaseHematoxylin and Eosintotal cholesterol
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Authors
Limin Wei, Mitsuyoshi Yamamoto, Masaru Harada, Makoto Otsuki,