| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5903101 | Metabolism | 2016 | 11 Pages |
Abstract
RVX-208 increased 10 lipid classes in the plasma HDL fraction, without altering the concentrations of either apoA-I or HDL-cholesterol (HDL-C). RVX-208 delayed and reduced oral glucose absorption and endogenous glucose production, with plasma glucose maintained via reduced peripheral glucose disposal. If sustained, these effects may protect against the development of type 2 diabetes.
Keywords
T2DMALTLDL-CApoA-ILPCLPElysophosphatidylethanolamineHDL-CGLP-1S1PMCHGIPOGTTHbA1chsCRPEGFRMCHCMCVApoA-IILFTVLDLGM3LCATIDLrHDLGM3 gangliosidedihexosylceramidedhCermonohexosylceramidetrihexosylceramideFBEAMPKGGTCETPTHCHDLDHCRDWLPInuclear magnetic resonanceAMP-activated protein kinasereconstituted HDLhigh-density lipoproteinLC-ESI-MS/MSLiver function testOral glucose tolerance testASTAspartate aminotransferaseAlanine aminotransferaseApolipoprotein A-IApolipoprotein A-IIsphingomyelinSphingosine-1-phosphatebromodomain and extra-terminalNMRDihydroceramideType 2 diabetesType 2 diabetes mellitusdiacylglycerolCerceramidebody mass indexBMIDisposition indexInsulin sensitivity indexBETRed cell distribution widthphosphatidylinositolphosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserinelecithin-cholesterol acyltransferaseLysophosphatidylcholineLysophosphatidylinositolvery low-density lipoproteinIntermediate-density lipoprotein Low-density lipoproteinLDLGlucose metabolismmean corpuscular hemoglobinMHCMean corpuscular hemoglobin concentrationestimated glomerular filtration raterate of appearancerate of disappearanceGlycated hemoglobingastric inhibitory polypeptidecholesteryl ester transfer proteinhigh-sensitivity C-reactive proteinglucagon-like peptide 1PrediabetesClinical trialHDL-cholesterolLDL-cholesterolcholesteryl esterfree cholesterolCOHgamma-glutamyl transpeptidase
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Authors
Andrew L. Siebel, Si Khiang Trinh, Melissa F. Formosa, Piyushkumar A. Mundra, Alaina K. Natoli, Medini Reddy-luthmoodoo, Kevin Huynh, Anmar A. Khan, Andrew L. Carey, Gerrit van Hall, Claudio Cobelli, Chiara Dalla-Man, Jim D. Otvos, Kerry-Anne Rye,