| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5903144 | Metabolism | 2015 | 33 Pages |
Abstract
Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.
Keywords
VMHIRStri-iodothyronineTSHCCKJAK2VTANTSGLP-1CARTMCHLHApro-opiomelanocortinSTAT3PYYLEPRSF-1SHP2SOCS3Janus Kinase 2IGFBPLepRbUCPPTP1BTNFGnRHAMPKPI3KACCIGFBATFOXO1FGFPOMCNPYAgRPAMP-activated protein kinaseMAPKacetyl-CoA carboxylaseinsulin receptor substrateinterleukintrhWAT, White adipose tissuebrown adipose tissuethyroxineForkhead box O1cocaine- and amphetamine-regulated transcriptCNSsuppressor of cytokine signaling 3central nervous systemSteroidogenic factor 1fibroblast growth factorInsulin-like growth factortumor necrosis factorPhosphatidylinositol 3-kinaseArcLeptinsignal transducer and activator of transcription 3MetabolismObesitylateral hypothalamic areaventral tegmental areanucleus of the solitary tractarcuate nucleusthyrotropin-releasing hormoneGonadotropin-releasing hormoneluteinizing hormoneGrowth hormonemelanin-concentrating hormonethyroid stimulating hormoneEnergy homeostasisHypothalamusVentromedial hypothalamusProtein tyrosine phosphatase 1BUncoupling proteinmitogen-activated protein kinasepeptide YYagouti-related peptideglucagon-like peptide 1WATcholecystokininLeptin receptorNeuropeptide Y
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Authors
Hyeong-Kyu Park, Rexford S. Ahima,