Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903146 | Metabolism | 2015 | 34 Pages |
Abstract
The present document summarizes those findings regarding leptin resistance development and the role of this hormone in the development and maintenance of an obese state. Thus, we focused on the effect of the impaired leptin action on adipose tissue, liver, skeletal muscle and intestinal function and the accompanying relationships with diet-induced obesity. The involvement of some inflammatory mediators implicated in the development of obesity and their roles in leptin resistance development are also discussed.
Keywords
TLRB0AT1PTP1BASCT2Vagal afferent neuronsSGLT1Mct1pro-opiomelanocortinDIOVTACCKPOMCAgRPCNTFNPYinflammationToll-like receptorDietBlood–brain barrierBBBsuppressor of cytokine signaling 3ciliary neurotrophic factorArcObesityLeptin resistancemonocarboxylate transporter 1ventral tegmental areaarcuate nucleusVANpeptide transporter 1Protein tyrosine phosphatase 1BAgouti-related proteinPept1diet-induced obesitycholecystokininNeuropeptide Y
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Authors
Neira Sáinz, Jaione Barrenetxe, MarÃa J. Moreno-Aliaga, José Alfredo MartÃnez,