Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903155 | Metabolism | 2015 | 9 Pages |
Abstract
Leptin was initially best known for its role in energy homeostasis and regulation of energy expenditure. In the past few years we have realized that leptin also plays a major role in neuroendocrine regulation and bone metabolism. Here, we review the literature the indirect and direct pathways through which leptin acts to influence bone metabolism and discuss bone abnormalities related to leptin deficiency in both animal and human studies. The clinical utility of leptin in leptin deficient individuals and its potential to improve metabolic bone disease are also discussed. We are beginning to understand the critical role leptin plays in bone metabolism; future randomized studies are needed to fully assess the potential and risk-benefit of leptin's use in metabolic bone disease particularly in leptin deficient individuals.
Keywords
STAT3ACTHCocaine- and amphetamine-related transcriptLepRbJanus Kinase 2SHP2VMHSOCS-3FGF23pro-opiomelanocortinCARTJAK2TSHHAARTPOMCNPYPI3KmTORAMPKAgRPFOXO1Igf1MAPKAktBonehighly active antiretroviral therapysuppressor of cytokine signaling 3body mass indexBMIfibroblast growth factor 23insulin-like growth factor 1phosphatidylinositol 3 kinaseArcLeptinsignal transducer and activator of transcription 3mammalian target of rapamycinarcuate nucleus of hypothalamusadrenocorticotropic hormoneThyroid-stimulating hormoneGrowth hormoneVentromedial hypothalamusForkhead box protein O1protein kinase Bmitogen-activated protein kinaseadenosine monophosphate-activated protein kinaseOsteoporosisagouti-related peptideLeptin receptorNeuropeptide Y
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Authors
Jagriti Upadhyay, Olivia M. Farr, Christos S. Mantzoros,