Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

Article ID	Journal	Published Year	Pages	File Type
5903184	Metabolism	2013	6 Pages	PDF

Abstract

Our data suggest that irisin, in pharmacological concentrations, increases cell proliferation in mouse H19-7 HN cells via STAT3, but not AMPK and/or ERK, signaling pathways. By contrast, neither physiological nor pharmacological concentrations of irisin alter markers of hippocampal neurogenesis in mouse H19-7 HN cell lines.

Keywords

AMPK STAT3 ERK MAP2 AMP-activated protein kinase Signaling Irisin signal transducer and activator of transcription 3 Hippocampal neurogenesis microtubule-associated protein 2 extracellular signal-regulated kinase