Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903205 | Metabolism | 2015 | 33 Pages |
Abstract
Anorexia nervosa (AN) is a psychiatric illness with profound medical consequences. Among the many adverse physical sequelae of AN, bone health is impacted by starvation and can be permanently impaired over the course of the illness. In this review of skeletal complications associated with eating disorders, we discuss the epidemiology, neuroendocrine changes, adolescent vs. adult skeletal considerations, orthopedic concerns, assessment of bone health, and treatment options for individuals with AN. The focus of the review is the skeletal sequelae associated with anorexia nervosa, but we also briefly consider other eating disorders that may afflict adolescents and young adults. The review presents updates to the field of bone health in AN, and also suggests knowledge gaps and areas for future investigation.
Keywords
DHEAIOC25OHDDXAISCDFDAGnRHIGF-IdehydroepiandrosteroneQCTBMDEating disorderinsulin-like growth factor IAnorexia nervosaBone mineral densityQuantitative computed tomographydual-energy X-ray absorptiometryAnterior cruciate ligamentACLFood and Drug AdministrationSerum 25-hydroxyvitamin DBone healthbody mass indexBMIgonadotropin releasing hormonefollicular stimulating hormoneluteinizing hormoneGrowth hormoneFSHInternational Olympic Committee
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Authors
Abigail A. Donaldson, Catherine M. Gordon,