Splenectomy attenuates obesity and decreases insulin hypersecretion in hypothalamic obese rats

Article ID	Journal	Published Year	Pages	File Type
5903245	Metabolism	2015	12 Pages	PDF

Abstract

Results show that splenectomy attenuates the progression of the obesity modulating pancreas functions in MSG-obese rats.

Keywords

RBC kitt IL6 SNS N-nitro-l-arginine methyl ester RIA SPL iNOS NOS HCT WBC MSG TNFα LPS AUC BSA H&E IL1β ivGTT l-NAME PMA ROS insulin tolerance test intravenous glucose tolerance test insulin interleukin 1 beta interleukin 6 ITT con Islets radioimmunoassay Bovine albumin serum NK cells Natural killer cells sympathetic nervous system White blood cell count Spleen phorbol myristate acetate lipopolysaccharide Obesity area under the curve nitric oxide synthase hematocrit Hematoxylin and Eosin body weight C-reactive protein CRP Control monosodium glutamate Glucokinase Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

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Splenectomy attenuates obesity and decreases insulin hypersecretion in hypothalamic obese rats

Authors

Nayara de Carvalho Leite, Elisangela Gueiber Montes, Stefani Valéria Fisher, Cláudia Regina Capriglioni Cancian, Júlio Cezar de Oliveira, Marli Cardoso Martins-Pinge, Carla Cristine Kanunfre, Kleber Luiz Araujo Souza, Sabrina Grassiolli,