| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5903384 | Metabolism | 2015 | 26 Pages |
Abstract
Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained. Dietary macronutrient composition has been examined in a number of articles, and diets enriched in saturated fatty acids, and possibly in fructose, appear to be most consistently associated with the development of insulin resistance. However, mechanistic insights into the metabolic effects of such diets are lacking, and merit further study.
Keywords
TLRSFAMUFAIL-1βIL-6NF-κBAUCHomeostatic model assessmentPolyunsaturated fatty acidsPUFAsaturated fatty acidsmonounsaturated fatty acidsinterleukin-6Interleukin-1βDietary compositiontumor necrosis factor αToll-like receptorTNF-αnuclear factor κBInsulin resistancearea under the curveHOMAFatCarbohydrate
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Authors
James Deer, Juraj Koska, Marlies Ozias, Peter Reaven,