Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice

Article ID	Journal	Published Year	Pages	File Type
5903437	Metabolism	2014	9 Pages	PDF

Abstract

Taken together, these results suggested that scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet.

Keywords

ALT G6PD GSH CYP2E1 NADP GST CAT ADH FFA PAP ALDH2 p-AMPK HDL-C phosphorylated AMPK MDA SREBP-1c NADPH AMPK CDNB ACC FAS 1-chloro-2,4-dinitrobenzene AMP-activated protein kinase GSH-Px ROS ALD AST alanine transaminase aldehyde dehydrogenase 2 ALP Alkaline phosphatase acetyl-CoA carboxylase Scopoletin Free fatty acid fatty acid synthase Alcohol Alcohol dehydrogenase alcoholic liver disease aspartate transaminase Triglycerides SOD Superoxide dismutase cytochrome P450 2E1 Phosphatidate phosphohydrolase lactate dehydrogenase LDH malondialdehyde hepatic lipid metabolism NAD NADH nicotinamide adenine dinucleotide phosphate nicotinamide adenine dinucleotide, reduced form nicotinamide adenine dinucleotide phosphate, reduced form NAD, nicotinamide adenine dinucleotide Sterol regulatory element binding protein-1c high-fat Catalase HDL-cholesterol total cholesterol Glutathione glutathione-S-transferase glutathione peroxidase glucose-6-phosphate dehydrogenase Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice

Authors

Hae-In Lee, Kyeong Won Yun, Kown-Il Seo, Myung-Joo Kim, Mi-Kyung Lee,