Pre-diabetes in overweight youth and early atherogenic risk

Article ID	Journal	Published Year	Pages	File Type
5903485	Metabolism	2014	8 Pages	PDF

Abstract

Overweight adolescents with PD have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, moderated by insulin resistance and visceral adiposity, but independently driven by dysglycemia for LDL size. Associations between smooth muscle biomarkers and lipoproteins could be an early signal heralding the atherogenic process. It remains to be determined if correction of dysglycemia and associated lipoprotein abnormalities in obese youth could prove effective in halting this process.

Keywords

VLDL IGT VCAM-1 NGT HDL DEXA NHANES ICAM-1 OGTT IFG HOMA-IR nuclear magnetic resonance high-density lipoprotein Oral glucose tolerance test impaired glucose tolerance Impaired fasting glucose Dyslipidemia National Health and Nutrition Examination Survey normal glucose tolerance Triglycerides NMR dual energy X-ray absorptiometry body mass index BMI coefficients of variation very low-density lipoprotein Lipoproteins Low-density lipoprotein LDL VAT Obesity intercellular adhesion molecule-1 Vascular adhesion molecule-1 Adolescents Pre-diabetes Glycemia