Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903506 | Metabolism | 2012 | 11 Pages |
Abstract
The objectives were to prospectively assess determinants of apolipoproteins B (ApoB), A1 (ApoA1), and the ApoB/ApoA1 ratio in 797 healthy black and white schoolgirls from mean ages 10 to 19. There was prospective 9-year follow-up, with measures of ApoB at mean ages 10, 12, 14, 16 and 19, ApoA1 at mean ages 12, 14, 16, and 19, and assessment of annual reports of delayed menstrual cyclicity (â¥Â 42 days) from ages 14 to 19. Studies of 402 black and 395 white healthy schoolgirls were done in public and private schools, in urban and suburban Cincinnati. Black girls had lower ApoB, higher ApoA1, and lower ApoB/ApoA1. SHBG at age 14 in white and black girls was inversely correlated with the ApoB/ApoA1. At age 19, â¥Â 3 annual reports of menstrual delay â¥Â 42 days and metabolic syndrome were associated with higher ApoB and a higher ApoB/ApoA1 ratio. From ages 14 to 19, BMI and TG were independently positively associated with ApoB. Menstrual cyclicity â¥Â 42 days, metabolic syndrome, BMI, and TG were independently positively associated with ApoB/ApoA1 ratios, while black race was negatively associated. The atherogenic ApoB/ApoA1 ratio from ages 14 to 19 is lower in black girls, and positively associated with hyperandrogenism, menstrual cyclicity â¥Â 42 days, BMI, TG, and the metabolic syndrome, facilitating an adolescent approach to primary prevention of cardiovascular disease.
Keywords
VLDLcSHBGLDLcapoA1apoBHDLCDHEASCHDApolipoprotein A1Apolipoprotein Bcoronary heart diseasecardiovascular diseasetriglycerideCVDMetabolic syndromedehydroepiandrosterone sulfateconfidence intervalsMETSMultiple imputationsex hormone binding globulinhigh density lipoprotein cholesterollow density lipoprotein cholesterolVery low density lipoprotein cholesterol
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
John A. Morrison, Charles J. Glueck, Stephen R. Daniels, Paul S. Horn, Ping Wang,