Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5903537 | Metabolism | 2013 | 13 Pages |
Abstract
This analysis using pooled primary data demonstrates that metformin use reduces, while sulfonylurea use may be associated with an increased cancer risk in subjects with T2DM. These findings need to be confirmed in large-scale RCTs before they are translated into clinical practice.
Keywords
AMPKT2DMIGFBP-1NIHIGF-1RCTsPRISMAIGF-IR95% CIrandomized control trialsPreferred Reporting Items for Systematic Reviews and Meta-AnalysesRandom effectFixed effectInsulin like growth factor-1Cancer incidenceRelative riskDiabetes mellitusType 2 diabetes mellitusWorld Health Organization95% confidence intervalNational Institutes of HealthMeta-analysis Of Observational Studies in Epidemiologyodds ratioInsulin-like growth factor binding protein-1adenosine monophosphate-activated protein kinaseWHOMoose
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Authors
Bindiya Thakkar, Konstantinos N. Aronis, Maria T. Vamvini, Kelsey Shields, Christos S. Mantzoros,