Caffeic acid phenethyl ester reduces the activation of the nuclear factor ÎºB pathway by high-fat diet-induced obesity in mice

Article ID	Journal	Published Year	Pages	File Type
5903753	Metabolism	2012	9 Pages	PDF

Abstract

Overall, these findings indicate that CAPE exhibited anti-inflammatory activity that partly restores normal metabolism, reduces the molecular changes observed in obesity and insulin resistance, and therefore has a potential as a therapeutic agent in obesity.

Keywords

IRS-1 COX-2 COX-1 ALT IRS PMSF PFA IκB IKK HFD OGTT IKKβ inhibitor of nuclear factor kappa B IRS-2 PKCζ protein kinase Cζ anti-phosphotyrosine mTOR CAPE FFA Jnk c-Jun N-terminal kinase H&E MAPK NFκB Oral glucose tolerance test AST Alanine aminotransferase EDTA Ethylenediaminetetraacetic acid caffeic acid phenethyl ester Free fatty acids sodium dodecyl sulfate-polyacrylamide gel electrophoresis SDS-PAGE insulin receptor substrate insulin receptor substrate-1 ANOVA one-way analysis of variance tumor necrosis factor-α standard error of the mean high-fat diet Insulin receptor substrate-2 cyclooxygenase-1 Cyclooxygenase-2 TNF-α nuclear factor kappa B Anti-inflammatory activity phenylmethylsulfonyl fluoride SEM Insulin resistance mammalian target of rapamycin Hematoxylin and Eosin paraformaldehyde mitogen-activated protein kinase propolis insulin receptor