Curcumin pretreatment mediates antidiabetogenesis via functional regulation of adrenergic receptor subtypes in the pancreas of multiple low-dose streptozotocin-induced diabetic rats

Curcumin pretreatment exerts antidiabetogenetic effect via functional regulation of adrenergic receptor subtypes in the pancreas of MLD-STZ-induced diabetic rats. Curcumin-pretreated rats increased β-cell glucose response after MLD-STZ injection by up-regulation of insulinotropic β-adrenergic receptors and down-regulation of inhibitory α2-adrenergic receptors. Functional regulation of adrenergic receptor subtypes in pancreas modulate key cell signaling proteins (CREB and phospholipase C) and second messengers (cAMP, cGMP, and IP3) and improves pancreatic glucose sensing (insulin receptor and glucose transporter) and insulin secretion in response to increased metabolic demands.96