Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5904885 | European Journal of Medical Genetics | 2014 | 13 Pages |
Abstract
Unraveling the complex multifactorial and heterogeneous etiology of EA/TEF and associated features will require large cohorts of patients. Combined statistical analysis of component findings, genome sequencing, and genome wide association studies will elucidate new causal genetic defects and predisposing loci in the etiology within specific sub-populations. Improved knowledge of environmental risk factors, genetic predisposition and causal genetic syndromes may improve prediction and parental counseling, and prevent co-morbidity.
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Authors
Erwin Brosens, Mirjam Ploeg, Yolande van Bever, Anna E. Koopmans, Hanneke IJsselstijn, Robbert J. Rottier, Rene Wijnen, Dick Tibboel, Annelies de Klein,