A de novo 3.57Â Mb microdeletion in 8q12.3q13.2 in a patient with mild intellectual disability and epilepsy

A female patient, nine years of age, is reported with a history characterized by delay of psychomotor and speech development, mild to moderate intellectual disability and persistent sleep disturbances since the age of two. The patient showed facial dysmorphisms, a pectus excavatum and a sandal gap. Apart from lowered intelligence, neuropsychological functioning disclosed impaired attentional capacities and executive control as well as weak motor skills. Genome wide SNP array analysis revealed a 3.57 Mb de novo microdeletion in band q12.3 of chromosome 8. The long lasting sleep disorders turned out to originate from a rare juvenile epilepsy, continuous spike-waves during slow sleep (CSWS) syndrome, that includes the electrical status epilepticus in sleep (ESES) phenomenon. MRI-scanning of the brain showed no abnormalities.To the authors knowledge, this is the first report of a de novo 8q12.3q13.2 microdeletion syndrome that presents with ESES/CSWS.

► Female child with intellectual disability and de novo 8q12.3q13.2 microdeletion. ► Referral for developmental delay, disinhibited behaviours, nocturnal awakenings. ► Deletion size: 3.57 Mb. ► Persistent sleep disorders due to Electrical Status Epilepticus in Sleep (ESES). ► 8q12.3q13.2 Microdeletion syndrome associated with a rare form of juvenile epilepsy.