Association of TLR polymorphisms with bronchopulmonary dysplasia

Article ID	Journal	Published Year	Pages	File Type
5905079	Gene	2016	6 Pages	PDF

Abstract

Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia.

Keywords

SP-B SP-C TIRAP SP-A NICHD MBL SNPs BPD PRBC DNA TLRs EDTA deoxyribonucleic acid ethylenediaminetetra-acetic acid standard deviation interleukin NICU Oxygen therapy Bronchopulmonary dysplasia PCR-RFLP Sepsis Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Mannose binding lectin Neonatal mortality Preterm neonates neonatal intensive care unit Surfactant protein A surfactant protein C surfactant protein B Single nucleotide polymorphisms Packed red blood cell Toll-like receptors